Around‐the‐Clock Oral THC Effects on Sleep in Male Chronic Daily Cannabis Smokers
Research Subject: Sleep
Author: David A. Gorelick, Robert S Goodwin, Eugene Schwilke et al.
Publish Date: 2013
Background and Objectives: D9‐tetrahydrocannabinol (THC) promotes sleep in animals; clinical use of THC is associated with somnolence. Human laboratory studies of oral THC have not shown
consistent effects on sleep. We prospectively evaluated self‐reported sleep parameters during controlled oral THC administration to research volunteers.
Methods: Thirteen male chronic daily cannabis smokers (mean SD age 24.6 3.7 years, self‐reported smoking frequency of 5.5 5.9 (range 1–24) joint‐equivalents daily at study entry) were administered oral THC doses (20 mg) around‐the‐clock for 7 days (40–120 mg daily) starting the afternoon after admission. The St. Mary’s Hospital Sleep Questionnaire was completed every morning.
Plasma THC and 11‐OH‐THC (active metabolite) concentrations were measured in venous blood samples collected every evening. Changes in sleep characteristics over time and associations between sleep characteristics and plasma cannabinoid concentrations were evaluated with repeated measures mixed linear regression. Results: Higher evening THC and 11‐OH‐THC concentrations were significantly associated with shorter sleep latency, less difficulty falling asleep, and more daytime sleep the following day. In contrast, the duration of calculated and self‐reported nighttime sleep decreased slightly (3.54 and 5.34 minutes per night, respectively) but significantly during the study.
Conclusions: These findings suggest that tolerance to the somnolent effects of THC may have occurred, but results should be considered preliminary due to design limitations.Download PDF
Cannabidiol reverses the mCPP-induced increase in marble-burying behavior
Cannabidiol (CBD), one of the main components of Cannabis sp., presents clinical and preclinical anx…
Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice
Cannabidiol, a nonpsychoactive constituent of the Cannabis sativa plant, has been reported to act as…
Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine
Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. The most …
Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis
Enteric glial cells (EGC) actively mediate acute and chronic inflammation in the gut; EGC proliferat…
Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice
Cannabis extracts and several cannabinoids have been shown to exert broad antiinflammatory activitie…