Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis
Research Subject: Batten Disease
Author: M. Mecha, A. Feliú, P.M. Iñigo et al.
Publish Date: 2013
Inflammation in the central nervous system (CNS) is a complex process that involves a multitude of molecules and effectors, and it requires the transmigration of blood leukocytes across the blood–brain barrier (BBB) and the activation of resident immune cells.
Using this viral model of multiple sclerosis (MS), we demonstrate that CBD decreases the transmigration of blood leukocytes by downregulating the expression of vascular cell adhesion molecule-1 (VCAM-1), chemokines (CCL2 and CCL5) and the proinflammatory cytokine IL-1β, as well as by attenuating the activation of microglia.Download PDF
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