Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells

Research Subject: Cancer
Author: Sean D. McAllister, Calvin Chan, Ryan J. Taft et al.
Publish Date: 2005

Normal tissue toxicity limits the efficacy of current treatment modalities for glioblastoma multiforme (GBM). We evaluated the influence of cannabinoids on cell proliferation, death, and morphology of human GBM cell lines and in primary human glial cultures, the normal cells from which GBM tumors arise. The influence of a plant derived cannabinoid agonist, D9-tetrahydrocannabinol (D9-THC), and a potent synthetic cannabinoid agonist, WIN 55,212-2, were compared using time lapse microscopy.

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