Estradiol Decreases Cortical Reactive Astrogliosis after Brain Injury by a Mechanism Involving Cannabinoid Receptors

Research Subject: Traumatic Brain Injury
Author: Ana Belen Lopez Rodriguez, Beatriz Mateos Vicente, Silvana Y. Romero-Zerbo et al.
Publish Date: 2011

In this study, we have explored whether cannabinoid receptors are involved in the effects of estradiol on reactive astroglia. To test this hypothesis, the effects of estradiol, the cannabinoid CB1 antagonist/inverse agonist AM251, and the cannabinoid CB2 antagonist/inverse agonist AM630 were assessed in the cerebral cortex of male rats after a stab wound brain injury.

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