The Nonpsychoactive Cannabis Constituent Cannabidiol Is a Wake-Inducing Agent

Research Subject: Sleep
Author: Eric Murillo-Rodriguez, Raphael Mechoulam, Rene Drucker-Colin et al.
Publish Date: 2008

Cannabidiol (CBD) is a constituent of Cannabis sativa that induces nonpsychotropic effects, and some of its biological actions in sleep have been described by the authors’ group. Here, the authors report that when administered 10 or 20 g/1 l during the lights-on period directly into either lateral hypothalamus (LH) or dorsal raphe nuclei (DRN), which are wake-inducing brain areas, CBD enhanced wakefulness and decreased slow wave sleep and REM sleep.

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