Study Suggests THC and CBC Exhibit Significant Antidepressant-like Effects

A 2010 study conducted by the Pharmacology Department at the Universty of Mississippi suggested that THC and other cannabinoids in the cannabis plant exert significant antidepressant-like effects.

Two in-vivo studies were conducted on mice dosed with various cannabinoids. The test were a forced swim test (FST) and a tail suspension test (TST). These tests were specifically chosen to induce symptoms in the mice comparative to human depression.

In the forced swim test, THC demonstrated significant antidepressant-like effects, as did CBC (cannabichromene) and CBD (Cannabidiol). However, CBG (cannabigerol) and CBN (cannabinol) did not produce any antidepressant-like effects.

In the tail suspension test, THC and CBC further exhibited significant antidepressant-like effects, with CBC also decreasing immobility in the subject.

The results of this study indicate that a range of cannabinoids, but especially THC and CBC exhibit significant antidepressant-like effects and further studies should be undertaken.

Read the full study on our Research Library here.

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